Nigeria Internationals, Victor Osimhen, Kelechi Iheanacho and Wilfred Ndidi would clash in the group stage of the Europa League after Leicester and Napoli were drawn against each other.
Rangers also face a daunting task againt Lyon while West Ham would settle scores with Genk and others.
See the full draw for the 2021/22 UEFA Europa League group stage, made in Istanbul on Friday:
Lyon (FRA), Rangers (SCO), Sparta Prague (CZE), Brondby (DEN)
Monaco (FRA), PSV Eindhoven (NED), Real Sociedad (ESP), Sturm Graz (AUT)
Napoli (ITA), Leicester City (ENG), Spartak Moscow (RUS), Legia Warsaw (POL)
Olympiakos (GRE), Eintracht Frankfurt (GER), Fenerbahce (TUR), Royal Antwerp (BEL)
Lazio (ITA), Lokomotiv Moscow (RUS), Marseille (FRA), Galatasaray (TUR)
Sporting Braga (POR), Red Star Belgrade (SRB), Ludogorets (BUL), Midtjylland (DEN)
Bayer Leverkusen (GER), Celtic (SCO), Real Betis (ESP), Ferencvaros (HUN)
Dinamo Zagreb (CRO), Genk (BEL), West Ham United (ENG), Rapid Vienna (AUT)